Subscribe: Latest / All - Designed by Dr James P Howard (Google+)
RITA-3 TRIAL |
|
|---|---|
| Problem | NSTEMI/UA (mod-high risk) |
| Format | Multi-center RCT |
| Treatment | Angiography +- PCI within 48h |
| Control | Medical therapy |
| Population | 1810 patients |
| Inclusion criteria | Suspected cardiac chest pain at rest and had documented evidence of coronary artery disease with at least one of: -Evidence of ischaemia on electrocardiograph (ST-segment depression, transient ST elevation, left bundle branch block [documented previously], or T-wave inversion) -Pathological Q waves suggesting previous myocardial infarction -Arteriographically proven coronary artery disease on a previous arteriogram. |
| Exclusion criteria | Those with probable evolving myocardial infarction, including those for whom reperfusion therapy was indic. Those in whom new pathological Q waves developed Those with creatine kinase or creatine kinase MB concentrations twice the upper limit of normal before randomisation Myocardial infarction within the previous month PCI in the preceding 12 months CABG at any time. |
| Follow-up | 5 years |
| Primary endpoint | Co-primary endpoints of: -combined rate of death, non-fatal myocardial infarction, or refractory angina at 4 months -Combined rate of death or non-fatal myocardial infarction at 1 year |
| Secondary endpoint(s) | Angina scores Quality-of-life scores Health-economic evaluations |
| Details | . |
| Brief summary: | PCI reduced death/MI in high risk patients, near-significant ACM reduction |
| PAPER: Interventional versus conservative treatment for patients with unstable angina or non-ST-elevation myocardial infarction: the British Heart Foundation RITA 3 randomised trial. | |
|---|---|
| Date | 7 Sep 2002 |
| Journal | Lancet. 2002 Sep 7;360(9335):743-51. |
| Information | Aniography +- PCI vs. conservative management N.B. In moderate/high risk groups -Significantly reduced death/MI/angina @ 4 months (RR=0.66; p=0.001) -Significantly reduced angina @ 4 months (RR=0.47; p<0.0001) & 1 year (RR=0.56; p=0.0002) -No significant difference in Death, MI @ 1 year (p=0.58) |
| PAPER: 5-year outcome of an interventional strategy in non-ST-elevation acute coronary syndrome: the British Heart Foundation RITA 3 randomised trial. | |
|---|---|
| Date | 10 Sep 2005 |
| Journal | Lancet. 2005 Sep 10-16;366(9489):914-20. |
| Information | PCI vs. conservative Mx @ 5yr N.B. Moderate/high risk patients only -Significantly reduced death/MI (RR=0.78; p=0.044) -Almost-significant reduction in death (RR=0.76; p=0.054) -Significantly reduced CV death (RR=0.026; p=0.026) and CV death/MI (RR=0.74; p=0.030) |