Key cardiology trials in evidence based medicine - click on a trial for more information or a topic above for a summary

Topic Therapy group Therapy Trial
Acute coronary syndromes ACE inhibitors Captopril ISIS-4
Lisinopril GISSI-3
Aldosterone antagonists Eplerenone EPHESUS
Anti-platelet therapy Aspirin ISIS-2, CURRENT-OASIS-7
Clopidogrel CURE, COMMIT, CURRENT-OASIS-7
Prasugrel TRITON-TIMI-38, TRILOGY-ACS, ACCOAST
Ticagrelor PLATO
Beta-blockers Atenolol ISIS-1
Metoprolol COMMIT
Diabetic control Insulin DIGAMI, DIGAMI-2
Glycoprotein IIbIIIa inhibitors In PCI CADILLAC, HORIZONS-AMI
Heparinoids Fondaparinux OASIS-6, OASIS-5
Heparin infusion ISIS-3, OASIS-6
Hirudin & Direct Thrombin Inhibitors Bivalirudin HORIZONS-AMI
Nitrates GTN GISSI-3
ISMN (MR) ISIS-4
PCI (STEMI) PCI post-thrombolysis NORDISTEMI
PCI to non-culprit arteries PRAMI
Thrombus aspiration TAPAS
PCI (UA/NSTEMI) PCI TACTICS-TIMI-18, RITA-3
Statins Atorvastatin PROVE-IT
Thrombolysis Streptokinase ISIS-2
Streptokinase, rtPA, Alterplase ISIS-3
Factor Xa inhibitors Rivaroxaban ATLAS-ACS-2-TIMI-51
Atrial Fibrillation Ablation Paroxysmal AF APAF, ThermoCool-AF
RFA (treatment naive) MANTRA-PAF
Anticoagulation Apixiban ARISTOTLE
Aspirin SPAF, SPAF-II
Dabigatran RE-LY
Rivaroxaban ROCKET-AF
Warfarin SPAF, SPAF-II, SPAF-III
Rate & Rhythm control Dronedarone ATHENA, PALLAS
Lenient vs strict rate control RACE-II
Rate vs. rhythm control AFFIRM
Coronary heart disease ACE inhibitors Ramipril HOPE
ACE inhibitors & ARBs Ramipril & Telmisartan ONTARGET
Angiotensin receptor blockers Telmisartan ONTARGET
Valsartan VALUE
Lipid therapy Niacin AIM-HIGH
Rosuvastatin SATURN
Simvastatin 4S
PCI 2-3 VD (vs. CABG) ASCERT
LMS/3VD (vs. CABG) SYNTAX
PCI (vs. medical therapy) COURAGE, FAME-2
T2DM - vs OMT/CABG BARI-2D, FREEDOM
Heart failure ACE inhibitors Enalapril CONSENSUS, SOLVD
ARBs Candesartan CHARM
Diastolic dysfunction CHARM, I-PRESERVE
Valsartan ValHeFT
Aldosterone antagonists Eplerenone (NYHA 2+) EMPHASIS-HF
Spironolactone (NYHA 3+) RALES
Anticoagulation Warfarin WARCEF
Beta-blockers Bisoprolol CIBIS-II
Carvedilol COMET
Devices CRT-D MADIT-CRT
ICD SCD-HeFT
Glycosides Digoxin DIG
If channel blockers Ivabradine BEAUTIFUL, SHIFT
Statins Rosuvastatin CORONA
Surgery CABG STITCH
Ultrafiltration Cardiorenal syndrome CARRESS-HF
Hypertension ACEi Benazepril ACCOMPLISH
Lisinopril ALLHAT
Prev. CVA/TIA PROGRESS
ARB Losartan LIFE
Valsartan VALUE
Alpha-blockers Doxazosin ALLHAT
CCB Amlodipine ALLHAT, VALUE
Nitrendipine Syst-Eur
Diet DASH diet DASH
Renal denervation Renal denervation Symplicity HTN-2, Symplicity HTN-3
Thiazides Chlorthalidone SHEP, ALLHAT
Hydrochlorothiazide ACCOMPLISH
Intervention Access Radial RIVAL
Antiplatelet cover Dual antiplatelet therapy PRODIGY
CAD (stable) 2-/3-VD (vs. CABG) ASCERT
3VD/LMS disease (vs. CABG) SYNTAX
MVD in DM vs. CABG FREEDOM
PCI (vs. medical therapy) COURAGE, FAME-2
T2DM - PCI vs OMT/CABG BARI-2D
Renal denervation Resistant hypertension Symplicity HTN-2, Symplicity HTN-3
STEMI Drug-eluting stents (vs. bare-metal) HORIZONS-AMI
PCI post-thrombolysis NORDISTEMI
PCI to non-culprit arteries PRAMI
Thrombus aspiration TAPAS
Stents Drug-eluting stents (1st generation) RAVEL, TAXUS-IV, COMPARE
Drug-eluting stents (2nd generation) COMPARE
TAVI Non-surgical AS patients PARTNER
Versus surgery in AS PARTNER
UA/NSTEMI PCI TACTICS-TIMI-18, RITA-3
Lipids ACS Atorvastatin PROVE-IT
CAD (stable) Niacin AIM-HIGH
Rosuvastatin SATURN
Simvastatin 4S
Heart failure Rosuvastatin CORONA
Primary prevention Ezetimibe ENHANCE
Rosuvastatin JUPITER
Primary prevention (T2DM) CARDS CARDS
Surgery CABG 2-3 VD (vs. PCI) ASCERT
CCF STITCH
LMS/3VD (vs. PCI) SYNTAX
MV disease in DM FREEDOM
T2DM - vs OMT & PCI BARI-2D